NEUROLOGY 1979;29:297
© 1979 American Academy of Neurology
The risk of epilepsy following febrile convulsions
John F. Annegers, Ph.D.,
W. Allen Hauser, M.D.,
Lila R. Elveback, Ph.D. and
Leonard T. Kurland, M.D.
Mayo Clinic and Mayo Foundation, Rochester, Minnesota.
A cohort of 666 children who had convulsions with fever were followed to determine the risks of subsequent epilepsy High risks were found in children with preexisting cerebral palsy or mental retardation. Other major risk factors were atypical features of the febrile convulsions (such as focal seizures) and duration of febrile seizures for 10 minutes or more. The risk of developing epilepsy by age 20 was about 6 percent for all children who had experienced febrile convulsions. However, this risk figure consisted of a combination of 2.5 percent of children without prior neurologic disorder or atypical or prolonged seizures, and 17 percent of those with such complications.
Requests for reprints should be sent to Dr. J. F. Annegers, Section of Medical Statistics, Mayo Clinic, 200 First Street SW, Rochester, MN 55901.
Accepted for publication June 15, 1978.
Supported in part by Research Grant N552327E.
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|
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|
|
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|
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|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
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|
|
|
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