Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bolton, C. F.
Right arrow Articles by Hahn, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bolton, C. F.
Right arrow Articles by Hahn, A.
NEUROLOGY 1979;29:354
© 1979 American Academy of Neurology

Nerve and muscle biopsy

Electrophysiology and morphology in polyneuropathy

C. F. Bolton, J. J. Gilbert, J. P. Girvin and A. Hahn

Departments of Clinical Neurological Sciences and Pathology, Victoria Hospital, University of Western Ontario, London, Ontario, Canada.

We correlated the results of biopsy of a muscle nerve, a sensory nerve, and tibialis anterior muscle with electrophysiologic studies in 13 patients with sensorimotor polyneuropathy and 6 patients with normal findings. There were significant correlations between teased fiber changes and conduction abnormalities in both muscle nerves and sensory nerves. The density of large myelinated fibers in the lateral fascicle of the deep peroneal (LFDP) nerve correlated significantly with both the motor unit estimate and compound action potential amplitude of the extensor digitorum brevis (EDB) muscle. Other characteristics of the EDB muscle compound action potential related poorly to teased fiber abnormalities. There was good correlation of needle electrode study of the EDB muscle with teased fiber analysis of the LFDP nerve and with the morphology of the tibialis anterior muscle in 75 percent of the cases, and only minor discrepancies in the remainder. These results emphasize the close relationship between certain structural and electrophysiologic changes in subacute and chronic polyneuropathy.

Dr. Bolton's address is Department of Clinical Neurological Sciences, Victoria Hospital, London, Ontario, Canada.

Presented in part at the eleventh World Congress of Neurology, Amsterdam, The Netherlands, September 11 to 16, 1977.

Accepted for publication July 10, 1978.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by AAN Enterprises, Inc.