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NEUROLOGY 1979;29:519
© 1979 American Academy of Neurology

Erythrocytes in Duchenne dystrophy

Osmotic fragility and membrane deformability

H. Somer, S. Chien, L. A. Sung and A. Thurn

H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York (Dr. Somer); and the Laboratory of Hemorheology, Department of Physiology, College of Physicians and Surgeons, Columbia University, New York (Drs. Chien, Sung, and Thurn).

Duchenne erythrocytes showed increased osmotic fragility as compared to controls (p < 0.01), but individual values overlapped with controls, and only half of the Duchenne erythrocyte values were abnormal. When the effect of the smaller mean corpuscular volume of Duchenne erythrocytes was taken into account, there was no significant difference from controls in membrane deformability, as determined by microsieving or flow channel measurements. The increased osmotic fragility suggests minor changes in erythrocyte membrane properties in Duchenne muscular dystrophy.

Dr. Chien's address is Laboratory of Hemorheology, Department of Physiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY, 10032.

This study was supported by Center grants from the NINCDS (No. NS-11766–04) and the Muscular Dystrophy Association, and by grants Nos. NHLBI-HL-16851 and NRSA HL-07114.

Presented in part at the twenty-ninth annual meeting of the American Academy of Neurology, April 1977, Atlanta, Georgia.

Accepted for publication June 19, 1978.






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