HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dodson, W. E. Articles by Siegel, B. A. Search for Related Content PubMed PubMed Citation Articles by Dodson, W. E. Articles by Siegel, B. A.

Radionuclide imaging in subacute sclerosing panencephalitis

Edward Mallinckrodt Department of Pediatrics, the Departments of Neurology and Neurological Surgery (Neurology), and the Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, and the Division of Pediatric Neurology of St. Louis Children's Hospital, St. Louis, Missouri.

Three patients with subacute sclerosing panencephalitis (SSPE)—two with acute disease and one with an exacerbation—had abnormal radionuclide brain scans during periods of rapid neurologic deterioration. In two of the three patients radionuclide brain scan showed lesions of both cortex and deeper structures, indicating the panencephalic nature of the disease. There was no contrast enhancement on computerized tomography (CT) in the areas of radiopharmaceutical accumulation in the two patients studied. We feel that delayed radionuclide scanning is more sensitive in detecting acute SSPE than routine contrast-enhanced CT, because more time is allowed for tracer accumulation in lesions and for background activity to decrease.