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Brain aluminum in aging and Alzheimer disease

Medical Research Council Demyelinating Diseases Unit, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom (Drs. McDermott and Smith), and the New York State Institute for Basic Research in Mental Retardation, Staten Island, New York (Drs. Iqbal and Wisniewski).

Aluminum was assayed by atomic absorption spectroscopy in 274 brain samples, and assayed in neurons isolated in bulk from the frontal cortex of patients with Alzheimer dementia and from age-matched patients with no neurologic disease. Brain aluminum concentration increased with age, from late middle age to old age. There were no statistically significant differences in brain aluminum concentration between the 10 patients with Alzheimer disease (mean, 2.7 µg per gram dry weight of tissue; mean age, 81 years), and the 9 nonneurological controls (mean, 2.5 µg per gram; mean age, 73 years). In both groups, the hippocampus had the highest concentration of aluminum (5.6 µg per gram), and the corpus callosum the lowest (1.5 µg per gram).

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