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Pseudotumor cerebri and insecticide intoxication

Department of Neurology, Medical College of Virginia, Richmond, Virginia.

Three patients with headache and increased intracranial pressure had elevated blood, serum, and adipose levels of the organochlorine insecticide chlordecone (Kepone). These patients were among 23 employees who suffered from chronic chlordecone intoxication resulting from industrial exposure. In our three patients, investigations eliminated an intracranial mass or other known causes of pseudotumor cerebri. In all three patients, the capacity for cerebrospinal fluid (CSF) absorption was assessed by graded infusions into the subarachnoid space, and was found to be impaired even when papilledema was minimal.

Address reprint requests to Dr. Selhorst, Box 698, Department of Neurology, Medical College of Virginia, Richmond, VA 23298.

This work was supported in part by a grant from the National Institutes of Health, NIEHS 5-R01-ES01519, and NIH contract N-01ES62117, and also by grants from Allied Chemical Corporation and Virginia Environmental Endowment.

Accepted for publication March 6, 1979.

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