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Delayed postischemic hypoperfusion

A potentially damaging consequence of stroke

Department of Neurology and the Research Center in Cerebrovascular Disease, Cornell University Medical College, New York, NY.

Cerebral blood flow (CBF) was assessed with radioactive butanol and antipyrine during and after 1 hour of unilateral carotid artery occlusion in gerbils. Animals with clinical evidence of stroke demonstrated a marked fall in ipsilateral CBF during occlusion "no-reflow" phenomenon did not develop; instead, blood flow returned to normal 5 minutes after the termination of carotid occlusion. Flow subsequently fell to half the control value, however, and remained depressed for several hours despite increased local metabolic demands. This delayed imbalance in energy supply and demand creates a potential for additional brain damage that might be prevented by appropriate therapeutic intervention.

Requests for reprints should be addressed to Dr. Levy, Department of Neurology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021.

This work was supported by NIH Grant No. NS-03346 and an Established Investigatorship from the American Heart Association with funds contributed in part by the New York Heart Association (Dr. Levy).

Presented in part at the thirtieth annual meeting of the American Academy of Neurology, Los Angeles, April 1978.

Accepted for publication February 28, 1979.

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