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Diagnosis of cryptococcal meningitis by cytologic methods

An old technique revisited

James Homer Wright Pathology Laboratories of the Massachusetts General Hospital and the Department of Pathology and Neurology-Neuropathology, Harvard Medical School, Boston.

In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on CSF examination. That patient had herpes simplex encephalitis on brain biopsy. Cytologic examination is recommended whenever cryptococcal meningitis is suspected.

Address reprint requests to Dr. Bernad, Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bldg 10, Room 10D18, Bethesda, MD 20205.

Accepted for publication May 3, 1979.