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Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges

Neurology Service, Veterans Administration Medical Center, and the Department of Neurology, University of Florida, College of Medicine, Gainesville, FL

Twenty-two patients with absence seizures and other seizure types were treated with valproic acid and followed up for 1 year. Results were excellent with more than 75% improvement in 80% of patients with absence seizures, in 400% of those with tonic-clonic seizures, in all of those with myoclonic seizures, and in 43% of those with partial seizures. Fifty-seven percent of the patients had more than a 75% reduction in the total number of paroxysmal spike-wave discharges, and 6% had more than a 75% reduction in the number of spike-wave discharges lasting longer than 3 seconds. Photosensitivity and activation by hyperventilation decreased. More patients achieved good EEG control in 1 year than in 10 weeks.

Address reprint requests to Dr. Wilder, Chief, Neurology Service, Veterans Administration Medical Center, Gainesville, FL 32602.

Accepted for publication June 11, 1979.

This work was supported by the Medical Research Service of the Veterans Administration and the Epilepsy Research Foundation of Florida, Inc. Dr. Bruni is sponsored by the Ministry of Health, Ontario, Canada.

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