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Immunocytochemical distribution of corticotropin (ACTH) in monkey brain

Departments of Neurology, (Drs. Abrams, Nilaver, Hoffman, and Zimmerman), Obstetrics, Gynecology, and Physiology, (Dr. Ferin), College of Physicians and Surgeons, Columbia University, and the Department of Medicine (Drs. Krieger and Liotta), Mount Sinai School of Medicine, New York, NY.

The distribution of adrenocorticotropin (ACTH) in monkey brain was examined by immunoperoxidase immunohistochemistry. An antiserum to ACTH that recognized the C-terminal portion of the molecule was used. Immunoreactive ACTH was visualized as an intraneuronal constituent with a widespread distribution throughout the brain. Reactive cell bodies were seen only in the region of the arcuate nucleus of the hypothalamus. Dense axonal networks were seen in the hypothalamus, mesencephalic gray, and in the region around the anterior commissure. No staining was seen in the cerebral cortex, cerebellum, hippocampus, or striatum. ACTH or fragments of ACTH may function as neurotransmitters or neuromodulators in primate brain.

Address correspondence and reprint requests to Dr. Zimmerman, Neurological Institute, Columbia University, 650 West 168th Street, New York, NY 10032.

Accepted for publication December 10, 1979.

This work was supported by USPHS Grants AM 20337, HD 05077, a Parkinson Research Foundation Grant to Columbia University, and the Lita-Hazen Annenberg Charitable Trust.

Presented in part at the thirty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1979.

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