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Department of Nutrition and Food Science, Laboratory of Neuroendocrine Regulation (Drs. Zeisel, Wurtman, and Magil), Massachusetts Institute of Technology, Cambridge, MA, and the Department of Neurology (Dr. Growdon and Ms. Logue), Tufts-New England Medical Center, Boston, MA.
we examined plasma choline changes after ingestion of diets composed of common foodstuffs, with choline contents bracketing the average daily intake in the American diet, and ingestion of diets supplemented with exogenous purified lecithin. A diet with low choline content did not increase plasma choline concentrations; a diet with high choline content doubled plasma choline levels. A lecithin-supplemented (25 gm; 80% phosphatidylcholine) low-choline diet increased plasma choline levels 400%, these findings indicate that normal diets cause only small elevations in plasma choline; purified lecithin supplements are likely to have greater effects in treating neurologic diseases.
Address correspondence and reprint requests to Dr. Wurtman, Department of Nutrition and Food Science, Room 56–245, M.I.T., Cambridge, MA 02139.
Accepted for publication January 31, 1980.
These studies were supported in part by grants (No. MH28783) from the National Institute of Mental Health, (No. NGR-22–009–627) from the National Aeronautics and Space Administration, and from the Wallace Genetic Foundation. Dr. Zeisel is a postdoctoral fellow supported by the National Institutes of Health (If32amo5756–03). Dr. Growdon is a Cotzias fellow of the American Parkinson's Disease Foundation. The M.I.T. Clinical Research Center is supported by the National Institutes of Health (No. M01-RR00088).
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