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Alteration of calcium transport in Duchenne erythrocytes

Department of Neurology, University of Pennsylvania, School of Medicine, and Children's Hospital of Philadelphia, PA.

Erythrocyte calcium transport as a function of free [Ca⁺⁺] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The K_m for Ca⁺⁺ of the transport protein and the V_max were higher in the Duchenne vesicles in seven of the eight pairs. The mean K_m and V_max were significantly higher in the Duchenne group.

Address correspondence and reprint requests to Dr. Mollman, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104.

Accepted for publication January 23, 1980.

This research was supported by United States Public Health Service Grants Nos. NS08075, HD08536, and RR05415, and by a grant from the Muscular Dystrophy Association of America. h. Mollman is a recipient of a Muscular Dystrophy Association Postdoctoral Fellowship.