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Endurance exercise training in a patient with central core disease

Departments of Neurology and Neurosurgery (Neurology), Pediatrics (Drs. Carroll and Brooke), and Preventive Medicine (Dr. Hagberg), the I. W. Johnson Rehabilitation Institute, and the Jerry Lewis Neuromuscular Research Center, Washington University School of Medicine, St. Louis, MO.

A 36-year-old man with central core disease underwent endurance exercise training on a bicycle ergometer for 9 months. The training resulted in an increase in work capacity and maximal oxygen consumption of approximately 50%. Further improvement in his exercise capacity seemed limited by the primary disease. These results suggest that some neuromuscular disease patients may benefit from endurance exercise training.

Address correspondence and reprint requests to Dr. Hagberg, Department of Preventive Medicine, Washington University School of Medicine, 4566 Scott Avenue, St. Louis, MO 63110.

Accepted for publication January 23, 1980.

This work was supported in part by a center grant from the Muscular Dystrophy Association. Dr. Hagberg was a postdoctoral fellow supported by NIH Fellowship No. HL-5689. Dr. Carroll is the recipient of an NIH Teacher Investigator Award No. 1 KO7 NS 00386.