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Aging and CSF hydroxylase cofactor

Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke (Drs. Williams and Caine), the Section on Biochemical Pharmacology, National Heart, Lung and Blood Institute (Mr. Levine and Dr. Lovenberg), National Institutes of Health, and the Psychobiology Branch, National Institute of Mental Health (Dr. Ballenger), Bethesda, MD.

The level of cerebrospinal fluid (CSF) hydroxylase cofactor activity was measured in 34 neurologically normal patients and analyzed according to age. Levels declined by approximately one-third over a 40-year span, probably reflecting loss of aminergic neurons. Fourteen patients with Parkinson disease all tended to have lower values than age-matched controls. Among Parkinson patients with the same order of disability, younger cases had higher CSF concentrations of hydroxylase cofactor than older patients.

Address correspondence and reprint requests to Dr. Calne, Experimental Therapeutics Branch, Room 6D20, Clinical Center, NIH, Betheeda, MD 20205.

Accepted for publication January 3, 1980.

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