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From the Laboratoire de Mélecine Expérimentale, CHU PitiéSalpétrière, Paris, France.
Tyrosine hydroxylase was used to identify catechol-aminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.
Address correspondence and reprint requests to Dr. Javoy-Agid, Laboratoire de Médecine Expéimentale, CHU Pitié-Salpétrière, 91, Bd de l'Hôpital, 75634 Pans CEDEX 13, France.
Accepted for publication February 19, 1980.
This research was supported by INSERM (ATP 76–71).
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