HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gastaut, H. Articles by Low, M. D. Search for Related Content PubMed PubMed Citation Articles by Gastaut, H. Articles by Low, M. D.

Lipomas of the corpus callosum and epilepsy

Service de Neurophysiologie Clinique, W. H. O. Collaborating Center for Teaching and Research in Neurology, Hopital de la Timone, Marseille, France (Drs. H. Gastaut, Regis, J. Gastaut, and Yermenos) and the Medical Research Council of Canada/French National Institute of Health and Medical Research (Dr. Low).

An analysis of four cases of lipomas of the corpus callosum with epilepsy, and a review of the literature, have led to the following conclusions: (1) Epilepsy as an almost constant feature is often severe, nearly always partial, and begins before the age of 15. (2) Pathophysiology of the seizures appears to be essentially an interhemispheric disconnection (rather than the classic theory that seizures depend upon an infiltration of the cingulate gyri by fibrous tissue growing out from the capsule of the lipoma). This disconnection is responsible for a facilitatory and disinhibitory action that favors the appearance of seizures caused by an epileptogenic lesion (the effects of which remain subthreshold in the presence of an intact corpus callosum playing its normal inhibitory role). This hypothesis is clearly applicable in explaining the epilepsies—in every way comparable—that are observed in agenesis of the corpus callosum and in Marchiafava-Bignami disease.

Address correspondence and reprint requests to Dr. Low, Division of Neurology, University of British Columbia, Vancouver, B. C., Canada V5Z 1M9.

Accepted for publication June 26, 1979.

This article has been cited by other articles:

				V. Ickowitz, D. Eurin, F. Rypens, P. Sonigo, I. Simon, P. David, F. Brunelle, and F. E. Avni Prenatal Diagnosis and Postnatal Follow-up of Pericallosal Lipoma: Report of Seven New Cases AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 767 - 772. [Abstract] [Full Text]

				M. Kieslich, S. Ehlers, M. Bollinger, and G. Jacobi Midline Developmental Anomalies With Lipomas in the Corpus Callosum Region J Child Neurol, February 1, 2000; 15(2): 85 - 89. [Abstract] [PDF]

				P.V. Choudary, S. Tsuji, B.M. Martin, B.C. Guild, R.C. Mulligan, G.J. Murray, J.A. Barranger, and E.I. Ginns The Molecular Biology of Gaucher Disease and the Potential for Gene Therapy Cold Spring Harb Symp Quant Biol, January 1, 1986; 51(0): 1047 - 1052. [Abstract] [PDF]