Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hochberg, F. H.
Right arrow Articles by Slotnick, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hochberg, F. H.
Right arrow Articles by Slotnick, B.
NEUROLOGY 1980;30:172
© 1980 American Academy of Neurology

Neuropsychologic impairment in astxocytoma survivors

Fred H. Hochberg, M. D. and Bennett Slotnick, Ph.D.

Neurology and Psychiatry Services, Massachusetts General Hospital (Dr. Hochberg), and the Harvard Medical School (Dr. Slotnick), Boston, MA.

Thirteen patients selected for long-term survival with primary astrocytic tumor (who failed to return to premorbid educational or vocational levels) were examined by neuropsychologic tests of specific and generalized higher cortical functions. In the absence of tumor regrowth or other neurologic disorders, each demonstrated difficulty in problem solving or coping with novel situations when previously acquired abilities, overlearned material, and psychometric intelligence appeared consistent with their premorbid level. The diffuse difficulties were unrelated to tumor type or location, and were not explicable by existing focal deficits, psychotic or depressive thought disorders, metabolic difficulties, or hydrocephalus. These examinations explained in part why these patients failed to resume active social lives or premorbid employment. The diffuse cortical dysfunction was most notable on the Category Test, Trails B, and Localization component of the Tactual Performance Test.

Address correspondence and reprint requests to Dr. Hochberg, Neurology Service, Massachusetts General Hospital, Boston, MA 02114.

Accepted for publication June 28, 1979.




This article has been cited by other articles:


Home page
 Neuro OncolHome page
I. Bosma, L. Douw, F. Bartolomei, J. J. Heimans, B. W. van Dijk, T. J. Postma, C. J. Stam, J. C. Reijneveld, and M. Klein
Synchronized brain activity and neurocognitive function in patients with low-grade glioma: A magnetoencephalography study
Neuro-oncol, January 1, 2008; 10(5): 734 - 744.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. G. Shaw, R. Rosdhal, R. B. D'Agostino Jr, J. Lovato, M. J. Naughton, M. E. Robbins, and S. R. Rapp
Phase II Study of Donepezil in Irradiated Brain Tumor Patients: Effect on Cognitive Function, Mood, and Quality of Life
J. Clin. Oncol., March 20, 2006; 24(9): 1415 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. P. O'Neill
Neurocognitive outcomes in primary CNS lymphoma (PCNSL)
Neurology, February 24, 2004; 62(4): 532 - 533.
[Full Text] [PDF]

Home page
 NeurologyHome page
I. J. Torres, A. J. Mundt, P. J. Sweeney, S. Llanes-Macy, L. Dunaway, M. Castillo, and R. L. Macdonald
A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors
Neurology, April 8, 2003; 60(7): 1113 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
C. A. Meyers and K. R. Hess
Multifaceted end points in brain tumor clinical trials: Cognitive deterioration precedes MRI progression
Neuro-oncol, April 1, 2003; 5(2): 89 - 95.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M.-c. Cheung, A. S. Chan, S. C. Law, J. H. Chan, and V. K. Tse
Cognitive Function of Patients With Nasopharyngeal Carcinoma With and Without Temporal Lobe Radionecrosis
Arch Neurol, September 1, 2000; 57(9): 1347 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A. R Giovagnoli
Quality of life in patients with stable disease after surgery, radiotherapy, and chemotherapy for malignant brain tumour
J. Neurol. Neurosurg. Psychiatry, September 1, 1999; 67(3): 358 - 363.
[Abstract] [Full Text]

Home page
 Neuro OncolHome page
B. P. O'Neill, C.-H. Wang, J. R. O'Fallon, J. P. Colgan, J. D. Earle, R. L. Krigel, L. D. Brown, and W. J. McGinnis
The consequences of treatment and disease in patients with primary CNS non-Hodgkin's lymphoma: Cognitive function and performance status
Neuro-oncol, July 1, 1999; 1(3): 196 - 203.
[Abstract] [PDF]

Home page
 FASEB J.Home page
F. Noel, G. J. Gumin, U. Raju, and P. J. Tofilon
Increased expression of prohormone convertase-2 in the irradiated rat brain
FASEB J, December 1, 1998; 12(15): 1725 - 1730.
[Abstract] [Full Text]

Home page
 J Child NeurolHome page
J. L. Ater, B. D. Moore, D. J. Francis, R. Castillo, J. Slopis, and D. R. Copeland
Correlation of Medical and Neurosurgical Events With Neuropsychological Status in Children at Diagnosis of Astrocytoma: Utilization of a Neurological Severity Score
J Child Neurol, November 1, 1996; 11(6): 462 - 469.
[Abstract] [PDF]

Home page
 RadiologyHome page
B. Movsas, B. S. Y. Li, J. S. Babb, B. L. Fowble, N. Nicolaou, and O. Gonen
Quantifying Radiation Therapy-induced Brain Injury with Whole-Brain Proton MR Spectroscopy: Initial Observations
Radiology, November 1, 2001; 221(2): 327 - 331.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.