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Hypoparathyroidism and elevated muscle enzymes

Departments of Medicine (Drs. Shane, McClane, and Bilezikian), and Neurology (Dr. Olarte), College of Physicians and Surgeons, Columbia University, New York, NY.

We studied a patient with hypocalcemia and increased serum activity of sarcoplasmic enzymes. Idiopathic hypoparathyroidism was established by history, low serum parathyroid hormone content, and marked responsiveness of urinary cyclic AMP and phosphate to parathyroid hormone. Muscle-associated isoenzymes of creatine phosphokinase and lactic dehydrogenase were increased, but there was no concomitant muscle weakness. Muscle biopsy was normal by morphologic and histochemical examination. The patient was treated with calcium and vitamin D. As the calcium rose, there were corresponding decreases in the serum activities of creatine phosphokinase and lactic dehydrogenase, with correlation coefficients of -0.88 and -0.64, respectively (p 0.01).

Address correspondence and reprint requests to Dr. Bilezikian, Department of Medicine 8–405, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032.

Accepted for publication July 13, 1979

This study was supported by NIH Grant No. RR00645. Dr. Bilezikian is Molly Berns Senior Investigator of the New York Heart Association and the recipient of Research Career Development Award No. 5 K04 HL-00383.

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