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Experimental gliomas

An autoradiographic study of the endothelial component

Department of Neurology, Northwestern University Medical School, Evanston Hospital, Evanston, IL (Dr. Groothuis, Ms. Fischer, and Dr. Vick) and the Department of Pathology (Neuropathology), Duke University, Durham, NC (Dr. Bigner).

Autochthonous gliomas were induced in rats by intracerebral inoculation of avian sarcoma virus and studied by ³H-thymidine autoradiography. Parenchymal glial tumor cells had a ³H-labeling index (LI) of 3.0 to 13.6%. Endothelial cells in tumor blood vessels had an LI of 2.6 to 34.3%, independent of and in most instances higher than the LI of the glial tumor. Endothelial cells of normal blood vessels had an average LI of 0.3%. This study documents the high proliferative rate of the endothelial cells in anaplastic experimental gliomas, and emphasizes the necessity for seeking direct, incontrovertible evidence to determine whether or not the rapidly proliferating endothelial cells are malignant.

Address correspondence and reprint requests to Dr. Groothuis, Division of Neurology, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201.

Accepted for publication July 12, 1979.

Presented in part at the thirty-first annual meeting of the American Academy of Neurology, Chicago, April 1979.

This work was supported by NIH grants Nos. NSCA 12745 (N. A. V.) CA11898, CA22790 (D. D. B.), and grants from the American Cancer Society (D. R. G.), the Boothroyd Foundation, and the Association for Brain Tumor Research.

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