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NEUROLOGY 1980;30:323
© 1980 American Academy of Neurology

Mechanical fragility of erythrocytes in multiple sclerosis

C. L. Schauf, H. Frischer and F. A. Davis

Departments of Physiology (Dr. Schauf), Medicine (Hematology), Pharmacology (Blood Genetics) (Dr. Frischer), and Neurological Sciences (Drs. Schauf and Davis), Rush University, Chicago, IL.

Erythrocyte fragility was measured by mechanical shaking in 82 normal individuals and 19 patients with multiple sclerosis (MS). On the average, fragility was significantly higher in the MS patients, although this increase did not correlate with the presence of serum neuroelectric blocking factors.

Address correspondence and reprint requests to Dr. Schauf, Rush University, Chicago, IL 60612.

Accepted for publication July 17, 1979.

Supported by USPHS grants Nos. R01NS12423 and HL 16005–06, by Research Career Development Award No. K04NS00004 (to Dr. Schauf), and by National Multiple Sclerosis Society grant No. 1230A1.







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