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Creutzfeldt-Jakob disease in a 20-year-old woman

Departments of Neurology (Drs. Packer, Cornblath, and Asbury), Pathology (Dr. Gonatas), and Neurosurgery (Dr. Bruno), University of Pennsylvania School of Medicine Philadelphia, PA.

A 20-year-old woman developed ataxia, extrapyramidal movements, myoclonus, and progressive dementia. Brain biopsy disclosed status spongiosus, diagnostic of Creutzfeldt-Jakob disease; this is the youngest spontaneous case ever reported. Creutzfeldt-Jakob disease can occur in young adulthood.

Address correspondence and reprint requests to Dr. Packer, Department of Neurology. University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

Accepted for publication August 14, 1979

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