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Search for Cytomegalovirus and herpes simplex virus genetic information in multiple sclerosis

Department of Health, Education and Welfare, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, Bethesda, MD (Drs. Aulakh and Albrecht), and Wadsworth VA Hospital, Los Angeles, CA (Dr. Tourtellotte).

Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary to these probes. These results indicate that the two viruses are not involved in MS, or else the genetic information, if present, is below the sensitivity of detection of this hybridization technique.

Address correspondence and reprint requests to Dr. Aulakh, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20205.

This research was supported in part by the National Multiple Sclerosis Society, VA Medical Research Fund, and by the NINCDS-NIMH Human Neurospecirnen Bank.

Accepted for publication September 4, 1979.