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Oligodendrocyte-binding antibodies in multiple sclerosis

¹²⁵I-protein A studies

Department of Neurology, University of Lausanne. Switzerland.

Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with ¹²⁵I-protein A. The mean binding of ¹²⁵I-protein A to oligodendrocytes was similar in MS and non-MS sera, but both were significantly higher than binding in controls. A hundredfold increase of ¹²⁵I-protein A binding over the preimmune value was obtained with a rabbit antioligodendrocyte antiserum. Oligodendrocyte-binding antibodies measured with ¹²⁵1-protein A do not appear to be a distinctive feature of MS.

Address correspondence and reprint requests to Dr. Steck, Department of Neurology. Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

This study was supported by the Swiss Multiple Sclerosis Society.

Accepted for publication August 14, 1979.