Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oda, K.
Right arrow Articles by Ito, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oda, K.
Right arrow Articles by Ito, Y.
NEUROLOGY 1980;30:543
© 1980 American Academy of Neurology

Myasthenia gravis

Antibodies to acetylcholine receptor with human and rat antigens

Kenichiro Oda, Ikuo Goto, Yoshigoro Kuroiwa, Kaoru Onoue and Yushi Ito

Department of Neurology (Drs. Oda, Goto, and Kuroiwa), Faculty of Medicine, the Department of Biochemistry (Dr. Onoue), Faculty of Dentistry, and the Department of Pharmacology (Dr. Ito), Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Serum antibodies to acetylcholine receptors (AChR) in myasthenia gravis were surveyed by radioimmunoassay, using 125I-{alpha}-bungarotoxin-complexed receptors of human muscles and denervated rat muscles. Antibodies were detected more frequently with human AChR than with rat AChR. Furthermore, antibody titers to human AChR were not always parallel to titers observed in the rat receptors, indicating the heterogeneity of antibody specificities in different individuals. Correlation between antibody titers and clinical severity was better when the antibody concentration was determined with human AChR. About 90% of the myasthenic sera contained antibodies to AChR, and 40% also contained other antibodies such as thyroid autoantibodies. These findings suggest that myasthenia gravis is a multiple immunopathy.

Address correspondence and reprint requests to Dr. Oda, Department of Neurology, Faculty of Medicine. Kyushu University, Fukuoka 812, Japan.

Accepted for publicalion August 14, 1979




This article has been cited by other articles:


Home page
 NEJMHome page
P. Siao and L. R. Zukerberg
Case 15-2000- A 69-Year-Old Man with Myasthenia Gravis and a Mediastinal Mass
N. Engl. J. Med., May 18, 2000; 342(20): 1508 - 1514.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.