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Department of Biopsychology (Mr. Wagner), the Department of Pharmacology and Physiology (Mr. Ricaurte and Dr. Sideden). and the Department of Psychiatry (Drs. Johanson and Schuster), University of Chicago, Chicago, IL.
Long-lasting depletion of dopamine and concomitant loss of dopamine uptake sites follow repeated administration of methylamphetamine to rats. We found similar effects after similar treatment with d-amphetamine, but not after treatment with methylphenidate. Methylphenidate also failed to produce long-term depletion of regional catecholamine levels in rhesus monkeys. These long-lasting alterations of the dopaminergic system suggest that amphetamines or their metabolites have toxic interactions with dopaminergic neurons, which do not occur with methylphenidate.
Address correspondence and reprint requests to Mr. Wagner, Department of Biopsychology, University of Chicago, 5848 South University Avenue, Chicago, IL 60637.
This study was supported in part by USPHS NIDA grants Nos. DA00250 and DA00085 and Research Scientist Awards DA00024 (C. R. Schuster) and MH10562 (L. S. Seiden). G. A. Ricaurte received support from the Insurance Medical Scientist Scholarship Fund (New York Life Insurance Co.).
Accepted for publication August 14, 1979.
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