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Protein binding Of valproic acid in uremic patients

Neurology Service, Veterans Administration Medical Center and the Department of Neurology (Drs. Bruni and Wilder), and the Division of Renal Medicine (Dr. Marbury), University of Florida College of Medicine, and the School of Pharmacy, University of Florida, (Ms. Wang and Dr. Lee) Gainesville, FL.

Protein binding of valproic acid was studied in four uremic patients on long-term hemodialysis. Before dialysis, the free fraction was 0.31 ± 0.11 (SD); this was larger than in nonuremic subjects. During hemodialysis, the free fraction increased significantly (p 0.01) in three patients (mean, 0.64 ± 0.32 SD).

Address correspondence and reprint requests to Dr. Bruni, Room 318 Jones Building, Wellesley Hospital, 160 Wellesley St. East, Toronto, Ontario, Canada M4Y 1J3.

This work was supported by the Medical Research Service of the Veterans Administration and the Epilepsy Research Foundation of Florida, Inc. Dr. Bruni is sponsored by the Ministry of Health, Ontario, Canada.

Accepted for publication August 10, 1979