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Anticonvulsant effects of muscimol

Department of Neurology. Washington University Medical School, St. Louis, MO.

Muscimol is a potent agonist at GABA-inhibitory synapses in mammalian brain. Given systemically at 7 µmol per kilogram, it blocks topical penicillin seizures and delays the onset of generalized metrazol convulsions in rats. It has no effect against generalized seizures caused by picrotoxin or strychnine. Higher doses of muscimol cause bradykinesia, ataxia, catatonic posturing, and slowing of the electroencephalogram. When applied topically to cortex, muscimol blocks focal penicillin, bicuculline, and picrotoxin discharges in a dose-response relationship. It has no effect against topical strychnine. Muscimol offers a potential new approach to the treatment of epilepsy.

Address correspondence and reprint requests to Dr. Collins. Department of Neurology, St. Louis City Hospital. 1515 Lafayette. St. Louis. MO 63104.

Supported by NINCDS grant No. NS14834.

Accepted for puhlication September 27. 1979.