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Disruption of the perineurium in amphibian peripheral nerve

Morphology and physiology

Departments of Neurological Sciences, Physiology, and Pathology, Rush University, Chicago, IL (Drs. Pencek, Schauf, Eisenberg, and Davis) and the Department of Neurology. Mayo Clinic, Rochester, MN (Dr. Low).

Removal of a small piece of perineurium in amphibian nerve causes a lesion consistent with the presence of extensive demyelination. Conduction velocity is reduced by 30 to 40%, and most of the fibers that still conduct are labile, with abnormally low blocking temperatures and unusual susceptibility to conduction block induced by changes in extracellular electrolytes. Application of drugs that inhibit the delayed K⁺ conductance restores conduction to fibers blocked by temperature elevation and ionic changes. This preparation may prove useful in studies of the pathophysiology of demyelinating diseases.

Address correspondence and reprint requests to Dr. Schauf, Professor of Physiology, Rush University, 1753 West Congress, Chicago, IL 60612.

This work was supported by USPHS Research Career Development Award No. K04NS00004 (Dr. Schauf), by National Multiple Sclerosis Society Grant No. RG1100A2 and the Morris Multiple Sclerosis Research Fund (Dr. Schauf) and by the Mayo Foundation and NIH grant No. NS 14304 (Peripheral Neuropathy Clinical Center, Dr. Low).

Accepted for publication September 18, 1979.

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