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Periodic lateralized epileptiform complexes (PLEDs) in Creutzfeldt-Jakob disease

Department of Neurology and EEG Laboratory, University of California Davis Medical Center, Sacramento, CA (Drs. Au, Gabor, and Vijayan), and the Department of Neurology, Indiana University School of Medicine, Indianapolis, IN (Dr. Markand).

The electroencephalogram (EEG) of three patients with typical Creutzfeldt-Jakob disease (CJD) was characterized by periodic lateralized epileptiform complexes (PLEDs), which persisted and became bilateral. This unusual pattern preceded the characteristic EEG change of CJD. Persistence of PLEDs should suggest the diagnosis of CJD.

Address correspondence and reprint requests to Dr. Gabor, EEG Laboratory, University of California Davis Medical Center, 2315 Stockton Boulevard, Sacramento, CA 95817.

Accepted for publication September 6, 1979.

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