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NEUROLOGY 1980;30:645
© 1980 American Academy of Neurology

Neurochemical analysis of cerebrospinal fluid

James H. Wood, M.D.

Division of Neurosurgery, University of Pennsylvania School of Medicine and Hospital, Philadelphia, PA.

The use of cerebrospinal fluid (CSF) analysis for studying in vivo alterations in central neuronal activity requires a relatively sophisticated knowledge of CSF physiology and pathology. Ventriculospinal concentration gradients, circadian rhythms, physical activity, stress, medications, precursor intake, concomitant illness, obstructed CSF circulation, age, and sex alter the baseline neurochemical composition of CSF. Differential probenecid blockade of the egress of acidic monoamine metabolites and cyclic nucleotides from the CSF may complicate interpretations of their accumulations. Degradation of CSF constituents during collection, storage, and analysis may introduce errors in quantification. These sources of CSF variability can be minimized with proper methodology.

Address correspondence and reprint requests to Dr. Wood, Division of Neurosurgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

Accepted for publication September 21, 1979.




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