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NEUROLOGY 1980;30:660
© 1980 American Academy of Neurology

EEG sleep alterations in olivopontocerebellar degeneration

John F. Neil, M.D., Barry C. Holzer, Duane G. Spiker, M.D., Patricia A. Coble, R.N. and David J. Kupfer, M.D.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

All-night polygraphic recordings of the electroencephalogram, horizontal electrooculogram, and submental electromyogram were performed in two patients with familial olivopontocerebellar degeneration. Sleep was characterized by subnormal measurements of both rapid eye movement (REM) and delta (slow-wave) sleep. Phasic eye movements were reduced out of proportion to tonic components of REM sleep. These findings lend further support to theories linking the pontine nuclei to the primary regulation of sleep in both experimental animals and humans.

Address correspondence and reprint requests to Dr. Neil, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15261.

Accepted for publication September 21, 1979.

Supported in part by NIMH grants Nos. MH25642 and MH30915.




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