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Department of Medical Statistica and Epidemiology (Dra. Annegers, Elveback, and KurIand) and the Department of Neurologic Surgery (Dr. Laws) and the Section of Electroencephalography (Dr. Grabow) and the Section of Pediatric Neurology (Dr. Groover), Mayo Clinic and Mayo Foundation, Rocheater, MN.
A cohort of 2747 patients with head injuries was followed for 28,176 person-years to determine the magnitude and duration of the risk of posttxaumatic seizures. Injuries were classified as severe (brain contusion, intracerebral or intracranial hematoma, or 24 hours of either unconsciousness or amnesia), moderate (skull fracture or 30 minutes to 24 hours of unconsciousness or amnesia), and mild (briefer unconsciousness or amnesia). The risk of posttraumatic seizures after severe injury was 7.1% within 1 year and 11.5% in 5 years, after moderate injury the risk was 0.7 and 1.6%, and after mild injury the risk was 0.1 and 0.6%. The incidence of seizures after mild head injuries was not significantly greater than in the general population.
Address correspondence and reprint requests to Dr. Annegers, Department of Medical Statistica and Epidemiology, Mayo Clinic, 200 Firat Street SW, Rochester, MN 66901.
Accepted for publication October 15, 1979.
This investigation was supported in part by Research Grant No. 52327 from the National Institutes of Health, Public Health Service.
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