HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Casey, D. E. Search for Related Content PubMed PubMed Citation Articles by Casey, D. E.

Pharmacology of blepharospasm-oromandibular dystonia syndrome

Departments of Medical Research, Pyschiatry, and Neurology, Veterans Administration Medical Center, and the University of Oregon Health Sciences Center, Portland, OR.

Blepharospasm and oromandibular dystonia are clinically similar to other hyperkinetic movement disorders. Dopaminergic antagonist (neuroleptic) and purported cholinergic agonist (deanol) treatment improved symptoms, whereas dopaminergic agonist (carbidopa/levodopa) and cholinergic antagonist (benztropine) drugs worsened symptoms in two patients. "his suggested that the syndrome is also pharmacologically related to the hyperkinetic dyskinesias. Symptoms worsened substantially during carbidopa/levodopa but temporarily resolved in one patient and improved in another when the drug was discontinued. This suggests that the pathophysiology of these symptoms involves an idiopathic form of receptor hypersensitivity that can be modified by agonist treatment. "he effect of cholinergic agents was less than the effect of dopaminergic drugs, implying that dopamine plays a predominant role in the pathophysiology.

Address correspondence and reprint requests to Dr. Casey, Department of Psychiatry, Veterans Administration Medical Center, Portland, OR 97201.

Accepted for publication October 19, 1979.

This investigation was supported in part by funds from the Veterans Administration Hospital Research Committee, Portland VA Medical Center, NINCDS Grant No. 14081, and The Grass Foundation.

This article has been cited by other articles:

				W. J. Weiner and P. A. Nausieda Meige's Syndrome During Long-term Dopaminergic Therapy in Parkinson's Disease Arch Neurol, July 1, 1982; 39(7): 451 - 452. [Abstract] [PDF]