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Antimigraine drugs and cranial arteriovenous shunting in the cat

Department of Pharmacology, Faculty of Medicine, Erasmus University, Rotterdam, the Netherlands.

The effects of three antimigraine drugs—ergotamine, dihydroergotamine, and methysergid—mn the distribution of flow throughout the cephalic circulation of the cat were studied, using microspheres of a suitable size to separate capillary flow from flow through the arteriovenous anastomoses. Ergotamine and dihydroergotamine significantly decreased the fraction of carotid blood flow shunted through the arteriovenous anastomoses, a mode of action that reemphasizes the need for further clinical studies on the involvement of arteriovenous anastomoses in the pathophysiology of migraine headaches.

Address correspondence and reprint requests to Dr. Spierings, Department of Pharmacology, Erasmus University, P.O. Box 1738, Rotterdam, the Netherlands.

Accepted for publication October 15, 1979.

Part of the ergotamine data was presented at the twenty-first annual meeting of the American Association for the Study of Headache, Boston, June 1979.

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