Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trotter, J. L.
Right arrow Articles by Gamey, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trotter, J. L.
Right arrow Articles by Gamey, W. F.
NEUROLOGY 1980;30:702
© 1980 American Academy of Neurology

Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis

John L. Trotter, M.D. and William F. Gamey, B.A.

Department of Neurology and Neurosurgery (Neurology), Washington University School of Medicine, St. Louis, MO.

Three daily 1-gm doses of methylprednisolone were administered to 12 patients with multiple sclerosis. Granulocytes, lymphocytes, T and B lymphocytes, lymphocyte transformation in response to several mitogens and one antigen, plasma cortisol, and serum IgM and IgA all returned to baseline within a few days. However, total white blood count, unstimulated lymphocyte incorporation of 3H-thymidine, hematocrit, serum IgM, and cerebrospinal fluid IgG synthesis remained altered 1 week after the infusion. The relationship of these changes to any clinical effects is unknown.

Address correspondence and reprint requests to Dr. Trotter, Department of Neurology and Neurosurgery (Neurology), Box 8111, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110.

Accepted for publication October 11, 1979.

Dr. Trotter is a recipient of a PHS Teacher-Investigator Award No. 5 KO7 NS00221–02 from NINCDS, NIH. This work was supported by the Kroc Foundation and the Washington University CRC Grant-PHS No. RR-36.




This article has been cited by other articles:


Home page
 NeurologyHome page
M. C. Ysrraelit, M. I. Gaitan, A. S. Lopez, and J. Correale
Impaired hypothalamic-pituitary-adrenal axis activity in patients with multiple sclerosis
Neurology, December 9, 2008; 71(24): 1948 - 1954.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
G. Abraham, F. Demiraj, and F. R. Ungemach
Comparison of the hypothalamic-pituitary-adrenal axis susceptibility upon single-dose i.m. depot versus long-acting i.v. triamcinolone acetonide therapy: a direct pharmacokinetic correlation.
J. Endocrinol., November 1, 2006; 191(2): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. H. Cross and W. M. Landau
John L. Trotter, MD (1943-2001)
Neurology, November 13, 2001; 57(9): 1534 - 1535.
[Full Text] [PDF]

Home page
 LupusHome page
W W Chatham and R P Kimberly
Treatment of lupus with corticosteroids
Lupus, March 1, 2001; 10(3): 140 - 147.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
C. E. Schwartz, B. F. Cole, and R. D. Gelber
Measuring Patient-Centered Outcomes in Neurologic Disease: Extending the Q-TWiST Method
Arch Neurol, August 1, 1995; 52(8): 754 - 762.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
A. Compston
Methylprednisolone and Multiple Sclerosis
Arch Neurol, June 1, 1988; 45(6): 669 - 670.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
R. Troiano, S. D. Cook, and P. C. Dowling
Steroid Therapy in Multiple Sclerosis: Point of View
Arch Neurol, August 1, 1987; 44(8): 803 - 807.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.