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Neurology Service and the C. S. Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, and the Department of Neurology-Neuropathology, Harvard Medical School, Boston, MA.
Article abetractSevere Broca aphasia and left hemiplegia without right limb apraxia occurred suddenly in a right-handed man with no personal or family history of left-handedness. Postmortem examination showed infarction of the right hemisphere, limited almost entirely to the precentral gyrus. In this patient, cerebral dominance for speech lay in the right hemisphere, but dominance for limb praxis lay in the left. This case provides evidence that cerebral dominance for speech and handedness in dextrals may be dissociated. It also suggests that lesions of the precentral gyrus are of major importance in producing Broca aphasia.
Address correspondence and reprint requests to Dr. Levine, Neurology Service, Maasachusetts General Hospital, Fruit Street, Boston, MA 02114.
Accepted for publication October 11, 1979.
This research was supported by grant No. NS-13102 of the National Institutes of Health and by a grant from the Rowland Foundation.
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