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Transplantation of human skeletal muscle to nude mice

A sequential morphologic study

Henry M. Watts Jr. Neuromuscular Disease Research Center and the Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA.

Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1,2,3,4,6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or triads. Leptomeres were also noted in some myotubes. By 4 weeks, cross-striation of myofilaments and migration of muscle nuclei to the periphery were observed. Distended sarcoplasmic reticulum and honeycomb structures oft tubules were noted between 4 and 8 weeks. This study indicates that mature human muscle can be transplanted successfully into nude mice, providing another tool for the investigation of human neuromuscular disease.

Address correspondence and reprint requests to Dr. Wakayama, Department of Neurology, Showa University, Fujigaoka Hospital, 1–30 Fujigaoka, Midori-Ku, Yokohama, 227, Japan.

Accepted for publication October 2, 1979.

Presented at the thirty-first annual meeting of the American Academy of Neurology, Chicago, IL, April, 1979

Supported by a Research Center Grant from the Muscular Dystrophy Association of America and by Grants Nos. NS-08075, NS-14471, and 5M01RR00040 from the US. Public Health Service.