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NEUROLOGY 1980;30:749
© 1980 American Academy of Neurology

Multiple sclerosis

Serum gamma globulin and demyelination in organ culture

Inge Grundke-Iqbal, Ph.D. and Murray B. Bornstein, M.D.

New York State Institute for Basic Research in Mental Retardation, Staten Island (Dr. Grundke-Iqbal), and the Department of Neurology, SUNY Downstate Medical Center, Brooklyn, and the Saul R. Korey Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY (Dr. Bornstein).

Multiple sclerosis (MS) sera frequently demyelinate organotypic central nervous system (CNS) tissue cultures. To elucidate the possible role of gamma globulins in this form of experimental demyelination we depleted MS sera of all gamma globulins by immunoabsorption and then compared their demyelinating activity with that of the unabsorbed sera. In only 2 out of 16 patients was some demyelinating activity detected in the gamma globulin fraction. In all patients, most of the demyelinating activity was not associated with gamma globulins. In gel filtration experiments, this non-gamma globulin activity was detected in a high-molecular-weight and in a lowmolecular-weight fraction.

Address correspondence and reprint requests to Dr. Grundke-Iqbal, New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, NY 10314.

Accepted for publication October 2, 1979

This investigation was supported by grant No. NS 11920 from the National Institutes of Health and a grant from the Alfred P. Sloan Foundation.




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