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Enlarged cerebral ventricular system in infant achondroplastic dwarf

Department of Neurology, Indiana University School of Medicine. IndianaDolis. IN.

The cause of the enlarged head found in achondroplastic dwarfs has been disputed. We studied an infant achondroplastic dwarf who had an enlarged (90%) head at age 2 months without enlarged cerebral ventricles. At age 10 months, her head size further enlarged (95%) and the cerebral ventricles were dilated. Megalencephaly may be the major factor contributing to the enlarged head in newborn achondroplastic dwarfs. Later, enlarged cerebral ventricles also contribute.

Address correspondence and reprint requests to Dr. Mueller, Regenstrief Center, 4th Floor, Indiana University, 1001 West 10th Street, Indianapolis, IN 46202.

Accepted for publication October 15, 1979.