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Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis

VA Medical Center, East Orange, and Department of Neurosciences, CMDNJ-New Jersey Medical School, Newark, NJ.

Address correspondence and reprint requests to Dr. Dowling, Neurology Service, VA Medical Center, East Orange, NJ 07019.

Intravenous steroid followed by oral prednisone was administered to patients with Guillain-Barré syndrome (five), acute transverse myelitis (three), and multiple sclerosis in acute relapse (seven). Preliminary experience with each of these disorders revealed prompt clinical improvement in some patients. The approach used in this uncontrolled study deserves further investigation.

Accepted for publication September 15, 1979.

Supported by Veterans Administration Project No. 1550–01, National Multiple Sclerosis Grant No. 1227-A-3, and Guillain-Barré Syndrome Foundation, Inc. No. A11.

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