Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lyons, M. J.
Right arrow Articles by Zabriskie, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lyons, M. J.
Right arrow Articles by Zabriskie, J. B.
NEUROLOGY 1980;30:92-98
© 1980 American Academy of Neurology

Induction of chronic neurologic disease in mice with canine distemper virus

Michael J. Lyons, William W. Hall, Carol Petito, Vinh Cam and John B. Zabriskie

Rockefeller University (Drs. Lyons, Hall, Cam, and Zabriskie), and the Department of Pathology (Neuropathology), Cornell University Medical College (Dr. Petito), New York, NY

Address correspondence and reprint requests to Dr. Lyons, The Rockefeller University, 1230 York Avenue, New York, NY 10021.

The capacity of a mouse-adapted strain of canine distemper virus (CDV) to induce central nervous system (CNS) disease in weanling mice was investigated. Lethality of infection was found to be mouse-strain-dependent. In sensitive strains, an acute meningoencephalomyelitis developed. Brain tissue from acutely ill animals demonstrated numerous foci of viral antigen, and extracts yielded infectious virus. Mice of resistant strains, notably the SJL strain, survived the effects of acute infection, appeared well for several weeks, and then began to develop signs of subacute CNS disease. Preliminary histopathologic examination of brain and cord from acutely ill animals revealed prominent perivascular mononuclear cell infiltrates, mononuclear cell meningitis, and gliosis. These features were also found in the subacute disease, where, however, the lesions were less severe. Also, in the latter, virus antigen could not be demonstrated. The results indicate that CDV infection of mice may provide a promising model system for the study of virus-induced chronic CNS disease.

Accepted for publication September 16, 1979.

Supported in part by Grant #529236 from the National Multiple Sclerosis Society. W. W. Hall is a Rita Allen Foundation Scholar.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.