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Multiple sclerosis

Evidence for immunopathogenesis

Department of Neurology, School of Medicine, University of Pennsylvania, and the Multiple Sclerosis Research Center of the University of Pennsylvania-Wistar Institute, Philadelphia, PA.

Address correspondence and reprint requests to Dr. Lisak, Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

I have attempted to review the evidence that one or more immunopathologic mechanisms are responsible for the clinical and pathologic findings in multiple sclerosis (MS). I believe that there is considerable evidence for an immunopathogenesis of MS, but it is not clear what type or types of reactions are involved or against which autoantigen, neoantigen, or microbial antigen the reaction is directed. In addition, there is growing evidence that there are abnormalities in immunologic control mechanisms in patients with MS, although whether these changes are a cause or a result of the disease is not clear.

Accepted for publication September 16, 1979.

This work was supported in part by U. S. Public Health Service grant No. NS 11037–07 and The National Multiple Sclerosis Society grant No. RG894-B-2.

This article has been cited by other articles:

				S. B. Elias Oligodendrocyte Development and the Natural History of Multiple Sclerosis: A New Hypothesis for the Pathogenesis of the Disease Arch Neurol, December 1, 1987; 44(12): 1294 - 1299. [Abstract] [PDF]