Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khurana, R. K.
Right arrow Articles by Garcia, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khurana, R. K.
Right arrow Articles by Garcia, J. H.
NEUROLOGY 1980;30:805
© 1980 American Academy of Neurology

Shy-Drager syndrome

Diagnosis and treatment of cholinergic dysfunction

Ramesh K. Khurana, M. D., Erland Nelson, M. D., Ph.D., Biagio Azzarelli, M. D. and Julio H. Garcia, M. D.

University of Maryland Hospital, Baltimore, MD.

Two patients with Shy-Drager syndrome demonstrated unusually widespread and unequivocal cholinergic dysfunction as well as the usual evidence of adrenergic insufficiency. Progressive constipation preceded impotence, nocturia, hesitancy in micturition, anhidrosis, orthostatic hypotension, and xerostomia. Nonautonomic neurologic signs appeared several years later. Cholinergic dysfunction involved eyes, lacrimal glands, salivary glands, heart, gastrointestinal tract, urinary bladder, and sweat glands. Subcutaneous administration of bethanechol chloride—a muscarinic receptor agonist—improved tearing, salivation, sweating, and gastrointestinal and bladder functions. Daily administration of this drug resulted in symptomatic improvement of the autonomic functions, and relapse followed discontinuation of treatment.

Address correspondence and reprint requests to Dr. Khurana, University of Maryland Hospital, 22 South Greene Street, Baltimore, MD 21201.

Accepted for publication October 24, 1979.




This article has been cited by other articles:


Home page
 The Journal of the Royal Society for the Promotion of HealthHome page
A. K. C. Leung, H. Y. H. Cho, M. C. K. Choi, and P. Y. H. Chan
Hypohidrosis in children
Perspectives in Public Health, June 1, 1999; 119(2): 101 - 107.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.