HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pro, J. D. Articles by Sumi, S. M. Search for Related Content PubMed PubMed Citation Articles by Pro, J. D. Articles by Sumi, S. M.

Presenile Alzheimer disease

Amyloid plaques in the cerebellum

Laboratory of Neuropathology, Department of Pathology (Dr. Sumi), and the Division of Neurology, Department of Medicine (Drs. Pro and Smith), University of Washington School of Medicine, Seattle, WA.

Seven of 24 patients with pathologically proved Alzheimer disease had amyloid plaques resembling kuru plaques in the cerebellum. In all seven patients, the dementia was presenile in onset, there was a positive family history of the disease in five patients, and other neurologic symptoms were present in five. Similar plaques have been described in one of two patients with familial Alzheimer disease from whom spongiform encephalopathy was induced in subhuman primates after intracerebral inoculation of brain tissue. These observations suggest that some cases of familial Alzheimer disease may be clinically distinct from senile dementia and may not be genetic in origin.

Address correspondence and reprint requests to Dr. Sumi, Laboratory of Neuropathology, Mail Stop RJ-05, University of Washington School of Medicine, Seattle, WA 98195.

Accepted for publication October 24, 1979.

Presented in part at the thirty-first annual meeting of the American Academy of Neurology, Chicago, April 1979.

This article has been cited by other articles:

				F. J. Huff, F. Boller, F. Lucchelli, R. Querriera, J. Beyer, and S. Belle The Neurologic Examination in Patients With Probable Alzheimer's Disease Arch Neurol, September 1, 1987; 44(9): 929 - 932. [Abstract] [PDF]

				P. St George-Hyslop, R. Tanzi, R. Polinsky, J. Haines, L Nee, P. Watkins, R. Myers, R. Feldman, D Pollen, D Drachman, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21 Science, February 20, 1987; 235(4791): 885 - 890. [Abstract] [PDF]