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NEUROLOGY 1980;30:832
© 1980 American Academy of Neurology

Naloxone overcomes the dopaminergic, EEG, and behavioral effects of {gamma}-hydroxybutyrahe

O. Carter Snead, III, M. D. and Larry J. Bearden, Ph.D.

Department of pediatrics (Dr. Snead), Biomedical Engineering (Dr. Bearden), and the Neuroscience Program, University of Alabama School of Medicine, Birmingham, AL.

The specific opiate antagonists—naloxone and naltrexone—attenuated or abolished the electrical seizure activity, behavioral abnormalities, and increased striatal dopamine content produced by {gamma}-butyrolactone, the prodrug of {gamma}-hydroxybutyrate. The effects of naloxone and naltrexone were dose-dependent. These data suggest that {gamma}-hydroxybutyric acid exerts its effects by action either at the opiate receptor or on enkephalinergic systems, which may be involved in petit mal epilepsy.

Address correspondence and reprint requests to Dr. Snead, 1601 6th Avenue South, Birmingham, AL 35233

Accepted for publication October 15, 1979.

Presented in part at the thirty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1979.




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O. Snead 3rd and L. Bearden
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