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Cigarette smoking and Parkinson disease

1. A comparison of cases with matched neighbors

Departments of Neurology (Drs. Baumann and Jameson) and Statistics (Dr. McKean) and the Tobacco and Health Research Institute (Drs. McKean and Haack and Ms. Weisberg), University of Kentucky, and the Lexington Veterans Administration Medical Center (Drs. Baumann and Jameson), Lexington, KY.

In previous studies, there were fewer cigarette smokers among persons with Parkinson disease than among other patients. We reinvestigated this phenomenon, using nonpatient controls. In home interviews with 237 Parkinson patients and 474 age-, sex-, and race-matched neighbors, we inquired about consumption of tobacco, coffee, tea, and alcohol. All Parkinson patients were diagnosed by a neurologist, had two or more cardinal features of parkinsonism, and had not received chronic phenothiazine therapy. One hundred fifty (63%) of 237 cases and 224 (47%) of 474 controls never smoked cigarettes (p < 0.0001). Significantly different smoking rates were also present at 10 and 20 years before the onset of parkinsonism.

Address correspondence and reprint requests to Dr. Baumann, Department of Neurology, MS 109, University of Kentucky, Lexington, KY 40536.

Accepted for publication October 15, 1979.

Presented at the thirty-first annual meeting of the American Academy of Neurology, Chicago, April 1979.

Supported by University of Kentucky Tobacco and Health Research Institute, Project No. KTRB 25134. Dr. Baumann was on leave from the University of Kentucky to the Section on Epidemiology, Office of Biometry and Epidemiology, NINCDS, Bethesda, MD, under the terms of the Intergovernmental Personnel Act (IPA) while part of this work was accomplished.

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