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NEUROLOGY 1980;30:867
© 1980 American Academy of Neurology

Fatal myeloencephalopathy caused by intrathecal vincristine

Howard Slyter, M. D., Boleslaw Liwnicz, M. D., Ph.D., Maie Kaarsoo Herrick, M. D. and Richard Mason, M. D.

Departments of Neurology (Dr. Slyter) and Pathology (Dr. Liwnicz), Stanford University Hospital, the Department of Pathology, Santa Clara Valley Medical Center (Dr. Herrick), and the Office of the Medical Examiner-Coroner (Dr. Mason), Santa Clara County, CA.

vincristine sulfate was inadvertently given intrathecally to a woman with lymphoma, producing ascending sensory and motor dysfunction followed by encephalopathy and death. Pathologically, neurons were swollen by aggregates of neurofilaments similar to the neurofilaments described in experimental models of vincristine neurotoxicity.

Address correspondence and reprint requests to Dr. Slyter, The Permanente Medical Group, 2200 O'Farrell Street, San Francisco, CA 94115.

Accepted for publication November 30, 1979.






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