Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rotrosen, J.
Right arrow Articles by Gershon, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rotrosen, J.
Right arrow Articles by Gershon, S.
NEUROLOGY 1980;30:878
© 1980 American Academy of Neurology

Experimental dystonia induced by quaternary-chlorpromazine

John Rotrosen, Michael Stanley, Cynthia Kuhn, David Wazer and Samuel Gershon

Neuropsychopharmacology Research Unit, Department of Psychiatry (Drs. Rotrosen, Stanley, Wazer, and Gershon), New York University Medical Center, New York, NY, and the Department of Pharmacology (Dr. Kuhn), Duke University Medical Center, Durham, NC.

When quaternary-chlorpromazine (Q-CPZ) was administered intraventricularly (ICV) to rats, it induced a lateralized dystonic reaction, which progressed to head-to-tail barrel rolling. The syndrome persisted for approximately 10 minutes, was not antagonized by pretreatment with drugs used to treat extrapyramidal movement disorders, and could not be mimicked by ICV administration of dopamine antagonists. Unlike known dopamine antagonists, Q-CPZ does not alter dopamine turnover, cause prolactin release in vivo, or bind to dopamine/neuroleptic receptors in vitro. These data suggest that Q-CPZ differs substantially from CPZ in pharmacologic action, and that it elicits a behavioral syndrome of potential use for studying dystonias.

Address correspondence and reprint requests to Lh. Rotrosen, Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY 10016.

Accepted for publication November 13, 1979.

These studies were supported in part by USPHS Grants Nos. MH-00137 and MH-07607 from the National Institute of Mental Health and by a grant from the Schizophrenia Research Program of the Scottish Rite Foundation.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by AAN Enterprises, Inc.