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NEUROLOGY 1980;30:882
© 1980 American Academy of Neurology

Demonstration of CSF gamma-globulin banding in presenile dementia

Adrian Williams, M. D., M. R. C. P., Nicholas Papadopoulos, Ph.D. and Thomas N. Chase, M. D.

Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, and the Clinical Pathology Department of the Clinical Center, National Institutes of Health, Bethesda, MD.

An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients.

Address correspondence and reprint requests to Dr. Chase. National Institutes of Health, 9000 Rockville Pike, Bldg. 36, Rm 5A31, Bethesda. MD 20205.

Accepted for publication October 31, 1979.






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