HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miller, J. R. Articles by Myers, J. C. Search for Related Content PubMed PubMed Citation Articles by Miller, J. R. Articles by Myers, J. C.

Amyotrophic lateral sclerosis

Search for poliovirus by nucleic acid hybridization

Department of Neurology (Dr. Miller), the Department of Microbiology (Dr. Guntaka), and the Institute of Cancer Research (Dr. Myers), College of Physicians and Surgeons, Columbia University, New York, NY.

Radioactive-labeled complementary DNA (cDNA) probes specific for either poliovirus type I or type II were hybridized with cellular RNA from the brains of patients dying of amyotrophic lateral sclerosis. In 11 brains examined, the percentage of hybridization for either polio type was the same as the percentage in normal brains. Although hybridization is a sensitive method for detection of viral genome material in infected cells, inability to detect viral nucleic acid by current techniques does not preclude the presence of viral genetic material in the tissue examined.

Address correspondence and reprint requests to Dr. Miller, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Accepted for publication November 9, 1979.

These investigations were supported by the Amyotrophic Lateral Sclerosis Society of America.

This article has been cited by other articles:

				W. A. Nix, M. M. Berger, M. S. Oberste, B. R. Brooks, D. M. McKenna-Yasek, R. H. Brown Jr., R. P. Roos, and M. A. Pallansch Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method Neurology, April 27, 2004; 62(8): 1372 - 1377. [Abstract] [Full Text] [PDF]

				H. Mitsumoto, M. R. Hanson, and D. A. Chad Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials Arch Neurol, February 1, 1988; 45(2): 189 - 202. [Abstract] [PDF]